All the Science Behind Kratom

Mitragyna speciosa kratom leaves growing in Southeast Asia.
Kratom is a tropical botanical derived from the leaves of the Mitragyna speciosa tree native to Southeast Asia. Over the past decade, kratom has gained attention throughout the United States as more people explore plant-based botanicals with long histories of traditional use.
Understanding the science behind kratom begins with learning about the plant itself, the natural alkaloids it contains, and how these compounds interact with the human body.
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Definition: Kratom is a botanical derived from the leaves of the Mitragyna speciosa tree native to Southeast Asia. The Science Behind It: Kratom’s effects come from naturally occurring alkaloids such as mitragynine and 7-hydroxymitragynine. These compounds interact with receptor systems related to mood, energy, and overall comfort. Examples:
Interesting Fact: Farmers in Southeast Asia have traditionally used kratom leaves during long workdays because of the plant’s balancing and energizing properties. |
Key Takeaways
- Kratom comes from the Mitragyna speciosa tree native to Southeast Asia.
- The plant contains over 40 alkaloids, with mitragynine and 7-hydroxymitragynine being the most studied.
- Kratom products come in several formats including powders, capsules, and extracts.
What Is Kratom?

Kratom capsules made from finely ground Mitragyna speciosa leaves.
Kratom comes from the leaves of the Mitragyna speciosa tree, a tropical evergreen plant native to Southeast Asia. The tree grows naturally in countries such as:
- Indonesia
- Thailand
- Malaysia
- Vietnam
For generations, farmers and laborers in these regions have traditionally used kratom leaves as part of daily routines.
Today, kratom is commonly available in several forms including kratom powder, kratom capsules, kratom extracts, and liquid kratom shots.
The Alkaloids Responsible for Kratom's Effects
Scientists have identified more than 40 alkaloids in kratom leaves. The two most studied compounds are mitragynine and 7-hydroxymitragynine.
Mitragynine
Mitragynine is the most abundant alkaloid in kratom leaves and contributes to many of the plant’s commonly reported properties.
7-Hydroxymitragynine
Although present in much smaller amounts, 7-hydroxymitragynine is considered one of the more potent alkaloids found in kratom.
These compounds interact with receptor systems throughout the body, which helps explain why kratom may produce a range of experiences depending on serving size and individual response.
How Kratom Interacts With the Body
Harvesting Kratom Leaves in Indonesia

Most kratom sold worldwide is harvested in Indonesia where Mitragyna speciosa trees grow naturally.
Kratom alkaloids interact with several receptor systems in the body including:
- Mu-opioid receptors
- Adrenergic receptors
- Serotonin receptors
Because of this complex interaction, kratoms effects are often described as dose dependent.
Lower Servings
- Increased energy
- Improved focus
- Elevated mood
Moderate to Higher Servings
- Relaxation
- Physical comfort
- A calming effect
Traditional Use of Kratom
Kratom has been used for centuries throughout Southeast Asia.
- Supporting energy during physical labor
- Promoting productivity
- Encouraging relaxation after work
Today, Indonesia is one of the largest producers of kratom used in international markets.
Different Types of Kratom Strains
Kratom products are often categorized by vein color.
Red Vein Kratom
Often associated with relaxing effects.
Green Vein Kratom
Known for balanced effects between energy and relaxation.
White Vein Kratom
Often described as more stimulating.
Choosing High-Quality Kratom
Because kratom is a natural botanical product, quality and sourcing are extremely important.
- Lab tested for purity
- Free from contaminants
- Sourced from reputable farms
- Processed using proper manufacturing standards
At NuWave Botanicals, we work directly with trusted farmers in Indonesia to provide premium kratom powder, convenient kratom capsules, and potent kratom extracts.
Frequently Asked Questions About Kratom
What plant does kratom come from?
Kratom comes from the leaves of the Mitragyna speciosa tree native to Southeast Asia.
What are kratom alkaloids?
Kratom alkaloids are naturally occurring compounds found in the leaves of the plant, including mitragynine and 7-hydroxymitragynine.
Where is kratom grown?
Most kratom sold in the United States is grown and harvested in Indonesia and surrounding Southeast Asian countries.
Disclaimer: Kratom products are not intended to diagnose, treat, cure, or prevent any disease. Effects may vary between individuals.