Kratom and 7-Hydroxymitragynine (7-OH) are often confused, but they are not equal in safety. Natural Kratom contains only trace amounts of 7-OH and is supported by centuries of traditional use and growing scientific study. In contrast, synthetic or highly concentrated 7-OH products are often unregulated, far more potent, and carry higher risks, side effects, and inconsistent dosing.
In this article, we’ll break down what is 7-Hydroxymitragynine vs Kratom debate, what sets Kratom apart as the safer alternative, explore research-backed concerns around synthetic 7-OH, and highlight the products that are trusted by many.
How Is 7-OH And Kratom Linked To Each Other?
Before answering this question, let’s understand what is 7-OH? And is it the same as Kratom? No, 7-Hydroxymitragynine is a naturally occurring alkaloid found in Kratom leaves, though only 2%. It is formed when Mitragynine, the most abundant active compound in Kratom, is metabolized. This conversion contributes to Kratom’s effects, especially its interaction with mu-opioid receptors.
The problem arises when the manufacturer isolates or synthesizes 7-OH separately, creating products with concentrations much higher than those found in nature. These synthetic forms behave differently in the body and may carry higher risks.
Kratom vs Synthetic 7-OH: What To Know
Understanding the difference between Kratom and synthetic 7-hydroxymitragynine (7-OH) is key when evaluating product safety. While both involve the same compound, their sources, strength, and processing methods vary significantly.
|
Feature |
Natural Kratom |
Synthetic 7-OH |
|
Active Compounds |
Contains multiple alkaloids, mainly mitragynine (~60%) and 7-hydroxymitragynine (typically <0.05%) [1] |
Contains only or primarily 7-OH, either synthetically produced or highly concentrated from kratom |
|
7-OH Levels |
Trace amounts — naturally occurring in very low concentrations [2] |
Highly concentrated or fully synthetic — up to 10x or more the potency of natural leaf |
|
Sourcing |
Naturally grown, harvested, and minimally processed (usually sun-dried and ground) |
Often lab-manipulated or chemically altered to increase 7-OH or mimic it synthetically |
|
Potency |
Balanced — full-spectrum effects due to multiple alkaloids working together (entourage effect) |
Extreme — effects are faster, more intense, and can be more sedating or euphoric |
|
Pharmacological Action |
Slower onset, broader receptor engagement (incl. adrenergic, serotonergic, dopamine) |
Highly selective mu-opioid agonist, mimicking stronger opioids in some cases [3] |
|
Safety Profile |
Long history of traditional use; generally well-tolerated in moderate doses |
Higher risk of side effects (e.g., sedation, respiratory depression) especially with synthetics [4] |
Important Notes:
- 7-hydroxymitragynine is not abundant in raw kratom. Even strong kratom strains contain less than 0.05% 7-OH.
- Synthetic or altered 7-OH can mimic or exceed the effect profile of potent opioids. This alters both tolerance potential and risk profile significantly.
- The "natural" kratom experience is a synergy of over 40 alkaloids — not a single compound like 7-OH.
-
A 2025 study led by Kirsten E. Smith found that synthetic or semi-synthetic 7-OH can pose public health risks. These products often lack dosage guidance and are not tested for consistency.
The Safer Path: Choose Natural Kratom Products
If you're looking for the benefits of Kratom without the uncertainty of synthetic 7-OH, sticking with natural, lab-tested products is the smarter route. These options maintain the natural balance of alkaloids—like mitragynine and 7-Hydroxymitragynine:
Zen K Shot
Crafted for convenience, the Zen K Shot is a pre-measured liquid Kratom extract made with naturally sourced ingredients. Designed for quick delivery without synthetic enhancements, it’s a balanced choice for those who want potency without going overboard.
OPMS Silver Green Maeng Da Kratom Powder
OPMS Silver Green Maeng Da Kratom Powder contains only natural, raw-leaf Kratom—no extracts, no synthetics. As part of the well-known Silver line, it offers reliable quality and a traditional Kratom profile that stays true to the plant’s original form.
EXP Bliss Shot
Part of the in-house EXP line, this shot is AKA-compliant, meaning it has been third-party tested and crafted with quality standards in mind. The EXP Bliss Shot focuses on clarity and consistency without crossing into synthetic territory.
MIT45 Boost Kratom Shot
Known for its clean formulation, MIT45 Boost offers a natural alkaloid blend with a caffeine-free energy boost. It avoids any artificial 7-OH concentrations, delivering only what you expect from a carefully controlled Kratom extract.
EXP Gummies
Looking for a more approachable form? EXP Gummies offer pre-measured, naturally formulated Kratom in a discreet edible format. Like other products, they are made from natural Kratom extracts and undergo thorough testing for purity.
All five of these standout products are available at NuWave Botanicals, where quality meets convenience. With AKA-approved brands, fast shipping, and perks like loyalty rewards and subscribe-and-save options, NuWave makes it easy to get top Kratom products without the wait—or the hassle.